- Title
- C1q and mobility score in predicting sarcopenia in an Australian cohort of cancer surgery patients
- Creator
- Senanayake, Tharindu; Loh, Eu Jhin; Carroll, Rosemary; Chan, Virgil; Smith, Stephen R.
- Relation
- ANZ Journal of Surgery Vol. 92, Issue 12, p. 3204-3208
- Publisher Link
- http://dx.doi.org/10.1111/ans.17658
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2022
- Description
- Background: Sarcopenia has been shown to have significant adverse health outcomes in a range of patient populations. Particularly, sarcopenic patients having cancer surgery are a unique group who demonstrate poorer post-operative outcomes. Currently, the gold standard in diagnosing sarcopenia is through the use of computed tomography. However, the widespread use of imaging to diagnose patients with sarcopenia is neither cost-effective nor practical. Identifying a serum biomarker or a simple mobility scoring system as an alternative diagnostic tool may aid in identifying more patients at risk of sarcopenia. C1q, a novel biomarker, has previously been shown to correlate with sarcopenia. Similarly, we sought to explore whether mobility scores may provide a useful surrogate marker for sarcopenia. Methods: This was a prospective cohort study of patients who presented for colorectal cancer surgery between the dates of 6/10/2016 and 4/10/2017 at John Hunter Hospital. Computed tomography was utilized to calculate the psoas area at the L3 spinal level. Pre-operative blood samples were obtained for C1q analysis and de Morton Mobility Index (DEMMI) was also performed. Results: A total of 51 patients were included in the study. The median age of the patients were 69 years old. We did not demonstrate a correlation between serum C1q and DEMMI scores with psoas area. Conclusion: Our findings suggest that neither C1q nor DEMMI scores are correlated with psoas area in a colorectal cancer population.
- Subject
- biomarkers; colectomy; colonic neoplasms; general surgery; sarcopenia; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1487485
- Identifier
- uon:52162
- Identifier
- ISSN:1445-1433
- Language
- eng
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